Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid peptide originally isolated from thymus gland tissue. This research-grade immunomodulatory peptide plays a crucial role in T-cell development, immune system regulation, and adaptive immunity. Currently approved for hepatitis B and C treatment in over 35 countries, Thymosin Alpha-1 has demonstrated remarkable versatility across multiple research domains including oncology, infectious diseases, neurodevelopment, and inflammatory conditions.

Research Applications & Scientific Mechanisms:

🛡️ Immune System Modulation Research:

• Restores immune function in athymic mouse models

• Activates fundamental immune signaling pathways and cytokine production

• Enhances vaccine efficacy and duration of immunity

• Sepsis mortality reduction and organ protection studies

• Dendritic cell maturation and antigen presentation research

🧠 Neurodevelopment & Cognitive Research:

• Promotes nerve growth and neurodevelopment in developing mammals

• Enhances cognitive function through peripheral administration

• Modulates genes responsible for neuron growth and connectivity

• Reduces neuroinflammation and dysfunction pathways

• Research applications in cerebral palsy and neurodevelopmental delays

🦠 Infectious Disease Research:

• Approved treatment for chronic hepatitis B and C (35+ countries)

• HIV research: CD8 T-cell stimulation and viral suppression

• Antifungal therapy enhancement through dendritic cell activation

• Aspergillus infection T-helper cell activation

• Vaccine adjuvant research for improved immune responses

🎯 Cancer Research Applications:

• Anti-proliferative effects in human lung cancer (A549) cells

• Reduces tumor growth and metastasis in multiple cancer types

• Enhances chemotherapy efficacy (dacarbazine combination studies)

• CD4/CD8 T-cell activation and interferon gamma production

• Research applications: breast, melanoma, liver, lung, and colon cancers

💊 Cardiovascular & Pain Research:

• ACE (Angiotensin Converting Enzyme) inhibition properties

• Blood pressure reduction and cardiac remodeling research

• Inflammatory pain pathway modulation

• TNF-alpha and IL-1beta cytokine reduction at inflammation sites

• Alternative pain relief mechanism research

🫁 Specialized Disease Research:

• Cystic fibrosis: CFTR protein function improvement

• Dental trauma: tooth replantation and tissue healing

• Anti-inflammatory applications across multiple conditions

• Autoimmune disorder research applications

Published Research Evidence:

• Demonstrated immune restoration in thymus-deficient models

• Significant mortality reduction in sepsis clinical studies

• Enhanced cognitive performance in developmental studies

• Anti-tumor effects across multiple cancer cell lines

• ACE inhibition comparable to pharmaceutical interventions

Product Specifications:

• Purity: ≥99% (HPLC/MS verified)

• Molecular Formula: C129H215N33O55

• Molecular Weight: 3108.3 g/mol

• Sequence: 28 amino acids (complete thymus-derived sequence)

• Format: Lyophilized white powder

• Storage: -20°C (long term), 2-8°C (short term)

• Stability: 36 months when stored properly

• Reconstitution: Sterile water or bacteriostatic water

• pH Range: 6.0-8.0 after reconstitution

• Solubility: Water soluble