Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid peptide originally isolated from thymus gland tissue. This research-grade immunomodulatory peptide plays a crucial role in T-cell development, immune system regulation, and adaptive immunity. Currently approved for hepatitis B and C treatment in over 35 countries, Thymosin Alpha-1 has demonstrated remarkable versatility across multiple research domains including oncology, infectious diseases, neurodevelopment, and inflammatory conditions.

Research Applications & Scientific Mechanisms:

🛡️ Immune System Modulation Research:

Restores immune function in athymic mouse models
Activates fundamental immune signaling pathways and cytokine production
Enhances vaccine efficacy and duration of immunity
Sepsis mortality reduction and organ protection studies
Dendritic cell maturation and antigen presentation research

🧠 Neurodevelopment & Cognitive Research:

Promotes nerve growth and neurodevelopment in developing mammals
Enhances cognitive function through peripheral administration
Modulates genes responsible for neuron growth and connectivity
Reduces neuroinflammation and dysfunction pathways
Research applications in cerebral palsy and neurodevelopmental delays

🦠 Infectious Disease Research:

Approved treatment for chronic hepatitis B and C (35+ countries)
HIV research: CD8 T-cell stimulation and viral suppression
Antifungal therapy enhancement through dendritic cell activation
Aspergillus infection T-helper cell activation
Vaccine adjuvant research for improved immune responses

🎯 Cancer Research Applications:

Anti-proliferative effects in human lung cancer (A549) cells
Reduces tumor growth and metastasis in multiple cancer types
Enhances chemotherapy efficacy (dacarbazine combination studies)
CD4/CD8 T-cell activation and interferon gamma production
Research applications: breast, melanoma, liver, lung, and colon cancers

💊 Cardiovascular & Pain Research:

ACE (Angiotensin Converting Enzyme) inhibition properties
Blood pressure reduction and cardiac remodeling research
Inflammatory pain pathway modulation
TNF-alpha and IL-1beta cytokine reduction at inflammation sites
Alternative pain relief mechanism research

🫁 Specialized Disease Research:

Cystic fibrosis: CFTR protein function improvement
Dental trauma: tooth replantation and tissue healing
Anti-inflammatory applications across multiple conditions
Autoimmune disorder research applications

Published Research Evidence:

Demonstrated immune restoration in thymus-deficient models
Significant mortality reduction in sepsis clinical studies
Enhanced cognitive performance in developmental studies
Anti-tumor effects across multiple cancer cell lines
ACE inhibition comparable to pharmaceutical interventions

Product Specifications:

Purity: ≥99% (HPLC/MS verified)
Molecular Formula: C129H215N33O55
Molecular Weight: 3108.3 g/mol
Sequence: 28 amino acids (complete thymus-derived sequence)
Format: Lyophilized white powder
Storage: -20°C (long term), 2-8°C (short term)
Stability: 36 months when stored properly
Reconstitution: Sterile water or bacteriostatic water
pH Range: 6.0-8.0 after reconstitution
Solubility: Water soluble