Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4-10), originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. This research-grade nootropic peptide has gained significant attention for its unique mechanisms involving brain-derived neurotrophic factor (BDNF), default mode network modulation, and neuroprotective properties.

Research Applications & Scientific Mechanisms:

🧠 Default Mode Network Research:

• Enhances resting brain network activity via fMRI studies

• Modulates social cognition and environmental monitoring systems

• Increases brain region interconnectivity and neural plasticity

• Potential applications in Alzheimer's and cognitive decline research

🔬 Gene Expression & Neuroplasticity:

• Affects 24 genes related to cerebrovascular function

• Stimulates nerve growth factor (NGF) and BDNF expression within 20 minutes

• Modulates gene expression in hippocampus and frontal cortex

• Research applications in neurogenesis and synaptic plasticity

🩺 Neuroprotective & Stroke Research:

• Promotes neuronal survival and mitochondrial stabilization

• Enhances cerebral blood flow and vascular function

• Accelerates functional recovery in stroke rehabilitation studies

• Research applications in traumatic brain injury and hypoxia models

💡 Cognitive Enhancement Studies:

• Protects learning and memory function in epilepsy models

• Potential nootropic properties independent of pathological conditions

• Research applications in executive function and concentration

• Memory consolidation and retrieval mechanism studies

🧬 Depression & Neurogenesis Research:

• Stimulates BDNF-mediated neurogenesis pathways

• Potential synergistic effects with SSRI treatment research

• Applications in understanding depression neurobiology

• Research into rapid-acting antidepressant mechanisms

Published Research Evidence:

• Demonstrated neuroprotective effects in stroke models

• Enhanced functional recovery in rehabilitation studies

• Rapid gene expression changes in cognitive brain regions

• BDNF elevation correlating with improved outcomes

Product Specifications:

• Purity: ≥99% (HPLC/MS verified)

• Molecular Formula: C37H51N9O10S

• Molecular Weight: 813.9 g/mol

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

• Format: Lyophilized white powder

• Storage: 2-8°C (short term), -20°C (long term)

• Stability: 36 months when stored properly

• Reconstitution: Sterile water or bacteriostatic water

• pH Range: 5.5-7.5 after reconstitution

• Solubility: Water soluble