Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4-10), originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. This research-grade nootropic peptide has gained significant attention for its unique mechanisms involving brain-derived neurotrophic factor (BDNF), default mode network modulation, and neuroprotective properties.

Research Applications & Scientific Mechanisms:

🧠 Default Mode Network Research:

Enhances resting brain network activity via fMRI studies
Modulates social cognition and environmental monitoring systems
Increases brain region interconnectivity and neural plasticity
Potential applications in Alzheimer's and cognitive decline research

🔬 Gene Expression & Neuroplasticity:

Affects 24 genes related to cerebrovascular function
Stimulates nerve growth factor (NGF) and BDNF expression within 20 minutes
Modulates gene expression in hippocampus and frontal cortex
Research applications in neurogenesis and synaptic plasticity

🩺 Neuroprotective & Stroke Research:

Promotes neuronal survival and mitochondrial stabilization
Enhances cerebral blood flow and vascular function
Accelerates functional recovery in stroke rehabilitation studies
Research applications in traumatic brain injury and hypoxia models

💡 Cognitive Enhancement Studies:

Protects learning and memory function in epilepsy models
Potential nootropic properties independent of pathological conditions
Research applications in executive function and concentration
Memory consolidation and retrieval mechanism studies

🧬 Depression & Neurogenesis Research:

Stimulates BDNF-mediated neurogenesis pathways
Potential synergistic effects with SSRI treatment research
Applications in understanding depression neurobiology
Research into rapid-acting antidepressant mechanisms

Published Research Evidence:

Demonstrated neuroprotective effects in stroke models
Enhanced functional recovery in rehabilitation studies
Rapid gene expression changes in cognitive brain regions
BDNF elevation correlating with improved outcomes

Product Specifications:

Purity: ≥99% (HPLC/MS verified)
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.9 g/mol
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Format: Lyophilized white powder
Storage: 2-8°C (short term), -20°C (long term)
Stability: 36 months when stored properly
Reconstitution: Sterile water or bacteriostatic water
pH Range: 5.5-7.5 after reconstitution
Solubility: Water soluble