SLU-PP-332 is a groundbreaking estrogen-related receptor (ERR) agonist that represents a major advancement in exercise mimetic research. This research-grade compound is the first ERRα agonist developed for in vivo applications, with exceptional bioavailability and an acceptable safety profile. As a pan-ERR agonist with primary activity at ERRα and ERRγ receptors, SLU-PP-332 directly impacts mitochondrial function, making it a revolutionary tool for studying cellular respiration, exercise mimetics, and anti-aging pathways.

Research Applications & Scientific Mechanisms:

🏃 Exercise Mimetic Research:

First viable "exercise in a bottle" compound targeting cellular respiration
70% increase in endurance capacity and 45% improvement in distance performance
Enhances mitochondrial density and efficiency without exercise intervention
12% body weight reduction in 30-day studies without dietary changes
Research applications in metabolic syndrome and exercise physiology

⚡ Mitochondrial Function & Cellular Energy:

Direct mitochondrial health improvement and energy generation enhancement
Increases mitochondrial density per cell through ERRγ activation
Reduces oxidative stress and free radical production
Enhanced oxygen and nutrient utilization at cellular level
Research applications in cellular aging and energy metabolism disorders

❤️ Cardiovascular Research:

Improved cardiac ejection fraction in heart failure models
Significant reduction in cardiac fibrosis and scar tissue formation
Enhanced fatty acid oxidation and cardiac energy homeostasis
Increased blood vessel density in skeletal muscle
Research applications in heart failure, cardiovascular disease, and cardiac protection

🧠 Neurological & Parkinson's Research:

Targets mitochondrial dysfunction in dopaminergic neurons
Addresses oxidative stress vulnerability in substantia nigra
Regulates genes for mitochondrial respiration, autophagy, and synaptic function
Research applications in Parkinson's disease, Lewy body dementia, and neurodegeneration
Potential therapeutic pathway for neurodegenerative disorders

🧬 Anti-Aging & Longevity Research:

Mimics caloric restriction benefits without dietary intervention
Protects against age-related mitochondrial dysfunction
Reduces inflammatory cytokines and albumin in urine
ERR signaling preservation associated with longevity
Research applications in cellular senescence, aging, and healthspan extension

🫀 Organ Protection Research:

Kidney function preservation and protection from aging effects
Autophagy regulation through transcription factor EB (TFEB)
Prevents accumulation of damaged cells and promotes healthy cell replacement
Research applications in organ preservation and regenerative medicine

🔬 Unique Research Advantages:

First ERRα agonist with in vivo bioavailability
Pan-ERR activity (α, γ primary; β secondary)
Superior bioavailability compared to previous ERR compounds
Acceptable safety profile for extended research applications
Pioneering compound in exercise mimetic field

Published Research Evidence:

70% endurance increase and 45% distance improvement in normal-weight mice
12% body weight reduction without exercise or dietary changes
Significant cardiac function improvement in heart failure models
Mitochondrial density increases and enhanced cellular energy production
Anti-aging effects equivalent to caloric restriction protocols