Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH) that acts as a potent agonist of melanocortin receptors. This research-grade peptide demonstrates remarkable versatility across multiple biological systems, with primary binding affinity for MC-1R, MC-4R, and weak binding to MC-3R. MT-2 has emerged as a crucial research tool for investigating melanocortin signaling pathways and their roles in diverse physiological and behavioral processes.

Research Applications & Scientific Mechanisms:

🧠 Autism Spectrum Disorder Research:

Reverses autistic behaviors in maternal immune activation (MIA) mouse models
Increases oxytocin receptor expression in specific brain regions
Restores social communication and reduces repetitive behaviors
Research applications in ASD pathway identification and treatment development
Oxytocin signaling pathway investigations in neurodevelopmental disorders

🍽️ Appetite & Metabolic Research:

Potent MC-4R agonist affecting food intake and preferences
Reduces fatty food consumption and overall caloric intake
Stimulates both leptin-dependent and leptin-independent satiety pathways
TRH (thyrotropin-releasing hormone) gene expression modulation
Superior CNS penetration compared to leptin for metabolic research

🩺 Diabetes & Glucose Metabolism Research:

Melanocortin-mediated glucose uptake enhancement
Glucagon suppression independent of insulin pathways
Ketone body formation pathway interference
Blood sugar regulation through central nervous system mechanisms
Alternative diabetes treatment pathway research

🍷 Impulse Control & Addiction Research:

Reduces alcohol intake in preference models
Synergistic effects with naltrexone (7-fold efficacy enhancement)
Binge-like ethanol consumption suppression studies
Research applications in craving and desire pathways
Oxytocin-mediated impulse control mechanisms

💊 Sexual Health & Dysfunction Research:

Central nervous system-mediated erectile function enhancement
80% response rate in sildenafil-resistant ED research models
Hypoactive sexual desire disorder research applications
MC-4R mediation of sexual behavior and function
Alternative mechanisms for sexual dysfunction research

🔬 Melanocortin Receptor Research:

MC-1R: Melanocyte stimulation and pigmentation studies
MC-4R: Feeding behavior and sexual function research
MC-3R: Appetite control and energy regulation investigations
Receptor binding affinity and selectivity studies
Comparative melanocortin pathway analysis

Published Research Evidence:

Complete reversal of ASD behaviors in established mouse models
Significant reduction in food intake and fatty food preference
Enhanced glucose metabolism independent of insulin pathways
Dramatic alcohol consumption reduction in addiction models
Superior efficacy in treatment-resistant erectile dysfunction cases

Product Specifications:

Purity: ≥99% (HPLC/MS verified)
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.2 g/mol
Structure: Cyclic heptapeptide
Format: Lyophilized white powder
Storage: -20°C (long term), 2-8°C (short term)
Stability: 36 months when stored properly
Reconstitution: Sterile water or bacteriostatic water
pH Range: 6.0-7.5 after reconstitution
Solubility: Water soluble