Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH) that acts as a potent agonist of melanocortin receptors. This research-grade peptide demonstrates remarkable versatility across multiple biological systems, with primary binding affinity for MC-1R, MC-4R, and weak binding to MC-3R. MT-2 has emerged as a crucial research tool for investigating melanocortin signaling pathways and their roles in diverse physiological and behavioral processes.

Research Applications & Scientific Mechanisms:

🧠 Autism Spectrum Disorder Research:

• Reverses autistic behaviors in maternal immune activation (MIA) mouse models

• Increases oxytocin receptor expression in specific brain regions

• Restores social communication and reduces repetitive behaviors

• Research applications in ASD pathway identification and treatment development

• Oxytocin signaling pathway investigations in neurodevelopmental disorders

🍽️ Appetite & Metabolic Research:

• Potent MC-4R agonist affecting food intake and preferences

• Reduces fatty food consumption and overall caloric intake

• Stimulates both leptin-dependent and leptin-independent satiety pathways

• TRH (thyrotropin-releasing hormone) gene expression modulation

• Superior CNS penetration compared to leptin for metabolic research

🩺 Diabetes & Glucose Metabolism Research:

• Melanocortin-mediated glucose uptake enhancement

• Glucagon suppression independent of insulin pathways

• Ketone body formation pathway interference

• Blood sugar regulation through central nervous system mechanisms

• Alternative diabetes treatment pathway research

🍷 Impulse Control & Addiction Research:

• Reduces alcohol intake in preference models

• Synergistic effects with naltrexone (7-fold efficacy enhancement)

• Binge-like ethanol consumption suppression studies

• Research applications in craving and desire pathways

• Oxytocin-mediated impulse control mechanisms

💊 Sexual Health & Dysfunction Research:

• Central nervous system-mediated erectile function enhancement

• 80% response rate in sildenafil-resistant ED research models

• Hypoactive sexual desire disorder research applications

• MC-4R mediation of sexual behavior and function

• Alternative mechanisms for sexual dysfunction research

🔬 Melanocortin Receptor Research:

• MC-1R: Melanocyte stimulation and pigmentation studies

• MC-4R: Feeding behavior and sexual function research

• MC-3R: Appetite control and energy regulation investigations

• Receptor binding affinity and selectivity studies

• Comparative melanocortin pathway analysis

Published Research Evidence:

• Complete reversal of ASD behaviors in established mouse models

• Significant reduction in food intake and fatty food preference

• Enhanced glucose metabolism independent of insulin pathways

• Dramatic alcohol consumption reduction in addiction models

• Superior efficacy in treatment-resistant erectile dysfunction cases

Product Specifications:

• Purity: ≥99% (HPLC/MS verified)

• Molecular Formula: C50H69N15O9

• Molecular Weight: 1024.2 g/mol

• Structure: Cyclic heptapeptide

• Format: Lyophilized white powder

• Storage: -20°C (long term), 2-8°C (short term)

• Stability: 36 months when stored properly

• Reconstitution: Sterile water or bacteriostatic water

• pH Range: 6.0-7.5 after reconstitution

• Solubility: Water soluble